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NGF

nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

Gene Name: nerve growth factor (beta polypeptide)
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: NGF, Beta-nerve growth factor, ProNGF, Beta-NGF, HSAN5, NGFB
Target Sequences: NM_002506 NP_002497.2 P01138

Publications (4)

1
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
2
Shp2-mediated MAPK pathway regulates ?Np63 in epithelium to promote corneal innervation and homeostasis. Yuka Okada, Yujin Zhang, Lingling Zhang, Lung-Kun Yeh, Yen-Chiao Wang, Shizuya Saika, Chia-Yang Liu. Laboratory investigation; a journal of technical methods and pathology. 2020 Apr;100:630-642. [Full Text Article] [PubMed:31653968] [PMC:PMC7102931] Related Antibodies: LS-C171793.
3
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily. Thomas Bitterli, David Schmid, Ladina Ettinger, Olga Krupkova, Frances C Bach, Marianna A Tryfonidou, Björn P Meij, Antonio Pozzi, Frank Steffen, Karin Wuertz-Kozak, Lucas A Smolders. JOR spine. 2024 March;7:e1292. [Full Text Article] [PubMed:38222814] [PMC:PMC10782068] Related Antibodies: LS-C388946.
4
Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation. Georgios Alkis Zisiadis, Androniki Alevyzaki, Elene Nicola, Carlos F D Rodrigues, Klas Blomgren, Ahmed M Osman. Frontiers in oncology. 2023 October;13:1202200. [Full Text Article] [PubMed:37860190]
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).