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Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Gene Name: | nuclear factor, erythroid 2 |
Synonyms: | NFE2, Leucine zipper protein NF-E2, NF-E2, p45 NF-E2, p45 |
Target Sequences: | NM_006163 NP_006154.1 Q16621 |
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