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Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
Gene Name: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Synonyms: | NFATC4, NF-ATc4, NFAT3, NF-AT3 |
Target Sequences: | NM_004554 NP_004545.2 Q14934 |
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