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NFATC1 / NFAT2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Gene Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Synonyms: NFATC1, NFATc, NFAT2, NF-ATC, NF-ATC transcription factor, NF-ATc1
Target Sequences: NM_006162 NP_006153.2 O95644

Publications (1)

1
Isolation and Characterization of Multipotent CD24+ Cells From the Renal Papilla of Swine. Burmeister DM, McIntyre MK, Montgomery RK, Gómez BI, Dubick MA. Frontiers in medicine. 2018 September;5:250. [Full Text Article] [PubMed:30283781] [PMC:PMC6156461]

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
NFATC1 / NFAT2 (7)
No (7)
GST, N-terminus (2)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NFATC1 / NFAT2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NFATC1 / NFAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.4 kDa
100 µg/$494
NFATC1 / NFAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
77.6 kDa
100 µg/$494
NFATC1 / NFAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.4 kDa
20 µg/$150
NFATC1 / NFAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
77.6 kDa
20 µg/$150
NFATC1 / NFAT2 Protein - Purified recombinant protein NFATC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
77.6 kDa
20 µg/$1,107
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).