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NF-L / NEFL

neurofilament, light polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Gene Name: neurofilament, light polypeptide
Synonyms: NEFL, 68 kDa neurofilament protein, CMT1F, CMT2E, NF68, NF-L, NFL, Neurofilament subunit NF-L, PPP1R110, Neurofilament light polypeptide, CMTDIG
Target Sequences: NM_006158 NP_006149.2 P07196

Publications (5)

1
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse) [PubMed:19427060]
2
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. The EMBO journal. 2011 30:4739-54. [PubMed:21946561] [PMC:PMC3243607]
3
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture. Lukiw WJ, Cong L, Jaber V, Zhao Y. Frontiers in neuroscience. 2018 December;12:896. [Full Text Article] [PubMed:30568571] [PMC:PMC6289986]
4
Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial10<sup> Department of Neurology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea12<sup> Lab for Neurodegenerative Dementia, Department of Anatomy, Ajou University School of Medicine, Suwon 16499, Republic of Korea14<sup> Department of Biomedical Systems Engineering, Korea Po. So Young Moon, Chang Hyung Hong, Jee Hyang Jeong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Byeong C Kim, Kyung Won Park, Hee Kyung Park, Muncheong Choi, Sun Min Lee, Buong-O Chun, Seong-Ho Koh , Sun Ah Park , Hyun-Hee Park, Jeong-Hwa Jin, Eun-Hye Lee, Sue Min Kim , Song Mi Han , Jun Seok Kim, Jungsoon Ha, Seong Hye Choi. Aging. 2021 Jun;13:15898-15916. [Full Text Article] [PubMed:34148030] [PMC:PMC8266338]
5
Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy. Seok Jong Chung , Tae Yong Lee, Yang Hyun Lee, KyoungWon Baik, Jin Ho Jung , Han Soo Yoo, Chang Jae Shim, Hyojin Eom, Ji-Yeon Hong, Dong Joon Kim, Young H Sohn, Phil Hyu Lee. Stem cells international. 2021 Oct;2021:9886877. [Full Text Article] [PubMed:34712335] [PMC:PMC8548132]
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ELISA Kits (21)
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NF-L / NEFL (21)
Human (6)
Mouse (3)
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Monkey (1)
Pig (1)
Porcine (1)
Rabbit (2)
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96-Well Microplate (2)
96-Well Strip Plate (18)
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Plasma (18)
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NF-L / NEFL ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NF-L / NEFL ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
4.94 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$811
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
NF-L / NEFL ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
NF-L / NEFL ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$750
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NF-L / NEFL ELISA Kit
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Competitive EIA
96-Well Microplate
Rabbit
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
NF-L / NEFL ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).