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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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Neuropeptide Y / NPY
neuropeptide Y
Neuropeptide Y / NPY is a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
| Gene Name: | neuropeptide Y |
| Family/Subfamily: | Pancreatic hormone , not assigned-Pancreatic hormone |
| Synonyms: | NPY, Pro-neuropeptide Y, Neuropeptide Y, PYY4 |
| Target Sequences: | NM_000905 NP_000896.1 P01303 |
Publications (1)
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