NEUROD1

neuronal differentiation 1

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.

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Products

Proteins (7)

Type

Over-Expression Lysate (3)

Recombinant (4)

Target

NEUROD1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human NEUROD1 Protein (Recombinant GST) (Full Length) - LS-G29495

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.3 kDa

Price:

2 µg/$439

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Human NEUROD1 Protein (Over-Expression Lysate His, N-Terminal) (Thr2-Asp356) - LS-G96883

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~40 kDa

Price:

100 µg/$298

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Human NEUROD1 Protein (Recombinant 6His, N-terminus) (Thr2-Asp356) - LS-G96881

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

37 kDa

Price:

10 µg/$265; 100 µg/$365; 50 µg/$315

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Human NEUROD1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66417

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.7 kDa

Price:

20 µg/$1,107

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Human NEUROD1 Protein (Recombinant GST, N-terminus) (aa201-300) - LS-G59383

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NEUROD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77645

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.7 kDa

Price:

20 µg/$150

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NEUROD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99775

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.7 kDa

Price:

100 µg/$494

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