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NELFA / WHSC2
negative elongation factor complex member A
NELFA / WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
| Gene Name: | negative elongation factor complex member A |
| Synonyms: | NELFA, Negative elongation factor A, NELF-A, P/OKcl.15, WHSC2 |
| Target Sequences: | NM_005663 NP_005654.3 Q9H3P2 |
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