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NEIL1

nei endonuclease VIII-like 1 (E. coli)

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Name: nei endonuclease VIII-like 1 (E. coli)
Synonyms: NEIL1, DNA glycosylase/AP lyase Neil1, Endonuclease VIII, Endonuclease 8-like 1, Endonuclease VIII-like 1, FPG1, HFPG1, Nei homolog 1, NEI1, Nei-like protein 1, NEH1
Target Sequences: NM_024608 NP_078884.2 Q96FI4

Publications (1)

1
Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor ?B-driven Gene Expression. Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos SA, Hazra TK, Hegde ML, Radak Z, Bacsi A, Brasier AR, Ba X, Boldogh I. The Journal of biological chemistry. 2016 December;291:25553-25566. [Full Text Article] [PubMed:27756845] [PMC:PMC5207254]

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
NEIL1 (9)
No (8)
Yes (1)
GST (1)
GST, N-terminus (1)
His (2)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (3)
NEIL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.5 kDa
100 µg/$494
NEIL1 Protein
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E. coli
His-SUMO
59.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NEIL1 Protein - Recombinant  Nei Endonuclease VIII Like Protein 1 By SDS-PAGE
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E. coli
His-T7
34.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
NEIL1 Protein - 12.5% SDS-PAGE of human NEIL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.1 kDa
10 µg/$479; 25 µg/$670
NEIL1 Protein - Purified recombinant protein NEIL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$1,107
NEIL1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
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293T Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$150
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E. coli
His
45 kDa
50 µg/$721
NEIL1 Protein
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E. coli
His
10 µg/$298; 50 µg/$417; 20 µg/$367; 100 µg/$564; 250 µg/$985; 500 µg/$1,480
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).