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NDUFA1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

Gene Name: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
Synonyms: NDUFA1, CI-MWFE, Complex I MWFE subunit, MWFE, NADH dehydrogenase, Type I dehydrogenase, ZNF183, Complex I-MWFE
Target Sequences: NM_004541 NP_004532.1 O15239

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
NDUFA1 (4)
No (4)
GST (2)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
NDUFA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
7.9 kDa
100 µg/$494
NDUFA1 Protein - 12.5% SDS-PAGE of human NDUFA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
30.91 kDa
10 µg/$479; 25 µg/$670
NDUFA1 Protein - 12.5% SDS-PAGE of human NDUFA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
33.44 kDa
10 µg/$479; 25 µg/$670
NDUFA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
7.9 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).