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Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity.
Gene Name: | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Synonyms: | NDST4, HSST4, NDST-4, N-HSST 4, NHSST4 |
Target Sequences: | NM_022569 NP_072091.1 Q9H3R1 |
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