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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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NCSTN / Nicastrin

nicastrin

NCSTN / Nicastrin is a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene Name: nicastrin
Family/Subfamily: Protease
Synonyms: NCSTN, Anterior pharynx-defective 2, ATAG1874, KIAA0253, Nicastrin, APH2, RP11-517F10.1
Target Sequences: NM_015331 NP_056146.1 Q92542

Viewing 1-25 of 44 items
NCSTN / Nicastrin Antibody - Anti-NCSTN / Nicastrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
NCSTN / Nicastrin Antibody - Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
Flo
PE Conjugated
25tst   0.1mg/ml   $235.00; 100tst   $315.00
NCSTN / Nicastrin Antibody
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
NCSTN / Nicastrin Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using NCSTN Polyclonal Antibody at dilution of 1:50.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.4mg/ml   $205.00; 60µl   0.4mg/ml   $235.00; 120µl   0.4mg/ml   $295.00; 200µl   0.4mg/ml   $395.00
Select
Mouse Monoclonal (IgG2b) to Mouse NCSTN / Nicastrin
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100µl   $455.00
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
ELISA, IF, WB
Unconjugated
100µg   $405.00
Select
Rabbit Polyclonal to Mouse NCSTN / Nicastrin
Mouse
ELISA, IHC, IHC-P
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ICC, IF
Unconjugated
50µl   $245.00; 100µl   $305.00
NCSTN / Nicastrin Antibody - Anti-NCSTN rabbit polyclonal antibody at 1:500 dilution. Lane A: Mouse brain tissue lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 78 kDa. Observed band size: 130 kDa.
Select
Rabbit Polyclonal (IgG) to Mouse NCSTN / Nicastrin
Mouse
ELISA, IP, WB
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
NCSTN / Nicastrin Antibody - Western blot of NCSTN pAb in extracts from mouse brain tissue and C6 cells.
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
NCSTN / Nicastrin Antibody - Immunohistochemistry of paraffin-embedded Human brain using NCSTN Polyclonal Antibody at dilution of 1:50.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.4mg/ml   $205.00; 60µl   0.4mg/ml   $235.00; 120µl   0.4mg/ml   $295.00; 200µl   0.4mg/ml   $395.00
Select
Mouse Monoclonal (IgG2b,k) to Human NCSTN / Nicastrin
Human
ELISA, WB
Unconjugated
100µl   $475.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ELISA, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
ELISA, WB
Unconjugated
100µl   $530.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
IP, WB
Unconjugated
50µl   $245.00; 100µl   $305.00
NCSTN / Nicastrin Antibody - Detection of human Nicastrin by western blot. Samples: Whole cell lysate (50 µg) from HeLa cells prepared using RIPA lysis buffer. Antibodies: Affinity purified rabbit anti-Nicastrin antibody used for WB at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IP, WB
Unconjugated
100µg   100µl   1mg/ml   $395.00
NCSTN / Nicastrin Antibody - All lanes: Anti-NCSTN Antibody (N-Term) at 1:8000 dilution. Lane 1: HL-60 whole cell lysates. Lane 2: HeLa whole cell lysates. Lane 3: C6 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 78 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Rat, Human
Peptide-ELISA, WB
Unconjugated
200µl   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse NCSTN / Nicastrin
Mouse, Rat
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
Flo
Unconjugated
50µl   $245.00; 100µl   $305.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ELISA
Unconjugated
100µl   $235.00; 200µl   $275.00; 400µl   $305.00
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ELISA
Unconjugated
50µl   $245.00; 100µl   $305.00
NCSTN / Nicastrin Antibody - WB of NCSTN / Nicastrin antibody. All lanes: Anti-NCSTN at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Predicted bind size: 78KD. Observed bind size: 78KD.
Select
Rabbit Polyclonal to Human NCSTN / Nicastrin
Rat, Pig, Horse, Bat, Bovine, Human
WB
Unconjugated
100µg   200µl   0.5mg/ml   $305.00
NCSTN / Nicastrin Antibody - Western blot analysis of extracts of various cell lines, using NCSTN antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Rat, Human
WB
Unconjugated
100µl   $315.00; 200µl   $425.00
NCSTN / Nicastrin Antibody - WB using Nicastrin Antibody
Select
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Dog, Human, Monkey, Chimpanzee, Orangutan
WB
Unconjugated
100µg   $395.00

Viewing 1-25 of 44 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).