NCOA1 / SRC-1

nuclear receptor coactivator 1

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

NCOA1 / SRC-1 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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NCOA1 / SRC-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

156.4 kDa

Price:

100 µg/$710

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Human NCOA1 / SRC-1 Protein (Recombinant GST, N-terminus) (aa284-393) - LS-G60808

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NCOA1 / SRC-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80698

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

156.6 kDa

Price:

20 µg/$215

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Human NCOA1 / SRC-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80699

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

156.4 kDa

Price:

20 µg/$215

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NCOA1 / SRC-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100112

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

156.6 kDa

Price:

100 µg/$710

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