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NCK1 / NCK
NCK adaptor protein 1
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
| Gene Name: | NCK adaptor protein 1 |
| Synonyms: | NCK1, Cytoplasmic protein nck, Cytoplasmic protein NCK1, NCK adaptor protein 1, Nck-1, NCKalpha, Melanoma NCK protein, NCK, NCK tyrosine kinase |
| Target Sequences: | NM_006153 NP_006144.1 P16333 |
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