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NCF2 / NOXA2 / p67phox
neutrophil cytosolic factor 2
NCF2 / NOXA2 / p67phox is neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | neutrophil cytosolic factor 2 |
| Synonyms: | NCF2, NADPH oxidase activator 2, Neutrophil cytosol factor 2, Neutrophil cytosolic factor 2, NOXA2, p67PHOX, NCF-2, p67-PHOX |
| Target Sequences: | NM_000433 NP_000424.2 P19878 |
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