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NAPRT

Nicotinate Phosphoribosyltransferase Domain Containing 1

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).

Gene Name: Nicotinate Phosphoribosyltransferase Domain Containing 1
Synonyms: NAPRT, FHA-HIT-interacting protein, NAPRTase, NAPRT1, PP3856, FHIP
Target Sequences: AF258565 AAG23768.1 Q6XQN6

Publications (1)

1
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. Cole J, Guiot MC, Gravel M, Bernier C, Shore GC, Roulston A. Oncotarget. 2017 September;8:77846-77859. (Human) [Full Text Article] [PubMed:29100430] [PMC:PMC5652819] Related Antibodies: LS-C139287.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).