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NAMPT / Visfatin

nicotinamide phosphoribosyltransferase

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Gene Name: nicotinamide phosphoribosyltransferase
Synonyms: NAMPT, PBEF, Pre-B cell-enhancing factor, VISFATIN, VF, NAmPRTase, PBEF1
Target Sequences: NM_005746 NP_005737.1 P43490

Publications (4)

1
Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment. Kieswich J, Sayers SR, Silvestre MF, Harwood SM, Yaqoob MM, Caton PW. Diabetologia. 2016 59:2477-2486. (WB; Mouse) [Full Text Article] [PubMed:27541013] [PMC:PMC5506101]
2
Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway. Duo Feng, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Rujie Qin, Saori Yonebayashi, Yuta Okabe, Siqi Li, Zixun Yuan, Kazutaka Aonuma, Masaki Ieda. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32629939] [PMC:PMC7370160]
3
Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model. Benoit Dechaumet, Damien Cleret, Marie-Thérèse Linossier, Arnaud Vanden-Bossche, Stéphanie Chanon, Etienne Lefai, Norbert Laroche, Marie-Hélène Lafage-Proust, Laurence Vico. PloS one. 2020 December;15:e0243098. [Full Text Article] [PubMed:33296408] [PMC:PMC7725345]
4
Effect of xylo-oligosaccharides on reproducibility, lipid metabolism, and adipokines of hens during the late egg-laying period. Fengyun Wen, Fengyan Wang, Pei Li, Hanyi Shi, Ning Liu. Animal bioscience. 2022 June; [Full Text Article] [PubMed:35760406]
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10 - 250 ng/ml
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0.1 - 1000 ng/ml
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0.313 - 20 ng/ml
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0.625 - 40 ng/ml
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1.56 - 100 ng/ml
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1.56 - 100 ng/ml
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31.2 - 2000 pg/ml
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1560 - 100000 pg/ml
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2.5 - 50 ng/ml
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125 - 8000 pg/ml
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7.813 - 500 pg/ml
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0.156 - 10 ng/ml
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0.313 - 20 ng/ml
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25 - 500 ng/ml
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0.156 - 10 ng/ml
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0.313 - 20 ng/ml
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1.563 - 100 ng/ml
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0.312 - 20 ng/ml
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1.1 - 300 ng/ml
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1.23 - 100 ng/ml
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1.23 - 100 ng/ml
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31.25 - 2000 pg/ml
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