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NALP4 / NLRP4

NLR family, pyrin domain containing 4

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Gene Name: NLR family, pyrin domain containing 4
Synonyms: NLRP4, Cancer/testis antigen 58, CLR19.5, CT58, PYPAF4, RNH2, NALP4, Ribonuclease inhibitor 2
Target Sequences: IPI00065552.2 Q96MN2

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
NALP4 / NLRP4 (3)
No (3)
Myc-DDK (Flag) (3)
Human (2)
293T Cells (1)
HEK 293 Cells (2)
NALP4 / NLRP4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
113.2 kDa
100 µg/$494
NALP4 / NLRP4 Protein - Purified recombinant protein NLRP4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
113.2 kDa
20 µg/$1,107
NALP4 / NLRP4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
113.2 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).