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May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
Gene Name: | NLR family, pyrin domain containing 4 |
Synonyms: | NLRP4, Cancer/testis antigen 58, CLR19.5, CT58, PYPAF4, RNH2, NALP4, Ribonuclease inhibitor 2 |
Target Sequences: | IPI00065552.2 Q96MN2 |
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