May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
|Gene Name:||NLR family, pyrin domain containing 4|
|Synonyms:||NLRP4, Cancer/testis antigen 58, CLR19.5, CT58, PYPAF4, RNH2, NALP4, Ribonuclease inhibitor 2|
|Target Sequences:||IPI00065552.2 Q96MN2|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.