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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NAK / TBK1

TANK-binding kinase 1

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

Gene Name: TANK-binding kinase 1
Family/Subfamily: Protein Kinase , IKAPPAB
Synonyms: TBK1, T2K, NAK, NF-kappa-B-activating kinase, NF-kB-activating kinase, TANK-binding kinase 1
Target Sequences: NM_013254 NP_037386.1 Q9UHD2

Publications (2)

1
TBK1 does not play a role in the control of in vitro Burkholderia pseudomallei growth. Panomket P, Splitter G, Harms J, Sermswan RW, Chedchotisakd P, Wongratanacheewin S. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008 S95-100. (WB) [PubMed:19121697]
2
Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease. Pottier C, Bieniek KF, Finch N, van de Vorst M, Baker M, Perkersen R, Brown P, Ravenscroft T, van Blitterswijk M, Nicholson AM, DeTure M, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Boylan KB, Boeve BF, Graff-Radford NR, Veltman JA, Gilissen C, Murray ME, Dickson DW, Rademakers R. Acta neuropathologica. 2015 130:77-92. (IHC; Human) [Full Text Article] [PubMed:25943890] [PMC:PMC4470809] Related Antibodies: LS-B1317.

Filtered by: None
Target
NAK / TBK1 (65)
Reactivity
Human (57)
Mouse (40)
Rat (32)
Bat (5)
Bovine (11)
Chicken (1)
Chimpanzee (6)
Dog (10)
Gibbon (6)
Guinea pig (9)
Hamster (5)
Horse (10)
Monkey (12)
Pig (11)
Rabbit (10)
Sheep (1)
Xenopus (1)
Zebrafish (5)
Application
IHC (33)
IHC-P (15)
WB (60)
ELISA (24)
ICC (1)
IF (2)
IP (1)
Peptide-ELISA (2)
Host
rabbit (61)
mouse (3)
goat (1)
Isotype
IgG (45)
IgG1,k (3)
Clonality
monoclonal mc (3)
polyclonal pc (62)
Clone
108A429 (2)
Format
AP Conjugated (3)
APC (1)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (4)
Unconjugated (30)
Epitope
Ser172 (8)
aa8-35 (8)
aa9-310 (8)
aa539-588 (4)
aa74-123 (4)
aa563-577 (2)
110-190 aa (1)
C-Terminus (1)
Internal (1)
aa138-187 (1)
aa514-527 (1)
aa577-590 (1)
aa675-C-term (1)
Publications
No (64)
Yes (1)
Showing 1-25 of 65 results

IHC-plus™ NAK / TBK1 Antibody (aa563-577, clone 108A429) LS-B1317
Publications (1)
Publications (1)
Mouse Monoclonal [clone 108A429] (IgG1,k) to Human NAK / TBK1
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-TBK1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ NAK / TBK1 Antibody (aa74-123) LS-B5859
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-TBK1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ NAK / TBK1 Antibody (aa539-588) LS-B5860
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-TBK1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TBK1 antibody Western blot of Fetal Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NAK / TBK1 Antibody (aa577-590) LS-C313237
Rabbit Polyclonal to Human NAK / TBK1
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Mouse, Guinea pig, Sheep, Bovine, Bat, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
NAK / TBK1 antibody. IHC(P): Rat Testis Tissue.
NAK / TBK1 antibody. IHC(P): Human Prostatic Cancer Tissue.

NAK / TBK1 Antibody (Ser172) LS-C99440
Rabbit Polyclonal to Human NAK / TBK1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human testis tissue reacted with TBK-pS172, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-TBK Antibody (S172) in K562 cell line lysates (35 ug/lane). TBK1(arrow) was detected using the purified antibody.

NAK / TBK1 Antibody (aa8-35, Biotin) LS-C224252
Rabbit Polyclonal (IgG) to Mouse NAK / TBK1
Mouse
ELISA, WB
Biotin Conjugated
200µl 0.5mg/ml  $740.00

NAK / TBK1 Antibody LS-C682262
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100
Immunofluorescent analysis of HeLa cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NAK / TBK1 Antibody (Biotin) LS-C679750
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

NAK / TBK1 Antibody (Ser172) LS-C327990
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

NAK / TBK1 Antibody (Ser172, Biotin) LS-C225953
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl 0.5mg/ml  $740.00

NAK / TBK1 Antibody (Ser172, FITC) LS-C225954
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
FITC Conjugated
200µl  $740.00

NAK / TBK1 Antibody (Ser172, APC) LS-C225951
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
APC Conjugated
200µl  $740.00

NAK / TBK1 Antibody (Ser172, AP) LS-C225952
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
AP Conjugated
200µl  $740.00

NAK / TBK1 Antibody (Ser172, PE) LS-C225955
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
PE Conjugated
200µl  $740.00

NAK / TBK1 Antibody (Ser172, Azide-free, HRP) LS-C225956
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

NAK / TBK1 Antibody LS-C153105
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Mouse, Rat, Human
WB
Unconjugated
100µg 1mg/ml  $435.00

NAK / TBK1 Antibody LS-C9269
Mouse Monoclonal (IgG1,k) to Human NAK / TBK1
Mouse, Human
WB
Unconjugated
100µg  $560.00

IHC-plus™ NAK / TBK1 Antibody (aa514-527) LS-B11263
Goat Polyclonal to Human NAK / TBK1
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-NAK / TBK1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
TBK1 antibody (1 ug/ml) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

NAK / TBK1 Antibody (C-Terminus) LS-C354510
Rabbit Polyclonal to Human NAK / TBK1
Mouse, Rat, Pig, Human, Monkey
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of TBK1 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.

IHC-plus™ NAK / TBK1 Antibody (aa138-187) LS-B12439
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Mouse, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100µl 1mg/ml  $505.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

NAK / TBK1 Antibody LS-C809629
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

NAK / TBK1 Antibody (aa563-577, clone 108A429, Azide-free) LS-C368304
Mouse Monoclonal [clone 108A429] (IgG1,k) to Human NAK / TBK1
Mouse, Dog, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated, Azide-free
100µg 0.5mg/ml  $365.00

NAK / TBK1 Antibody LS-C390
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Mouse, Human
ELISA, ICC, WB
Unconjugated
0.1mg  $365.00
Immunocytochemistry of NAK in MOLT4 cells with NAK antibody at 10 µg/ml.

NAK / TBK1 Antibody (HRP) LS-C370486
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Human
ELISA, IHC, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

NAK / TBK1 Antibody (110-190 aa) LS-C386318
Rabbit Polyclonal (IgG) to Human NAK / TBK1
Mouse, Human
ELISA, IHC
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Showing 1-25 of 65 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).