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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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NABP2
nucleic acid binding protein 2
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
| Gene Name: | nucleic acid binding protein 2 |
| Synonyms: | NABP2, LP3587, HSSB1, OBFC2B, Sensor of ssDNA subunit B1, SSB1, SOSS-B1, Nucleic acid binding protein 2, Nucleic acid-binding protein 2, SOSS complex subunit B1 |
| Target Sequences: | NM_024068 NP_076973.1 Q9BQ15 |
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