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NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
NAB2 is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
| Gene Name: | NGFI-A binding protein 2 (EGR1 binding protein 2) |
| Synonyms: | NAB2, EGR1 binding protein 2, MADER, Protein MADER, EGR-1-binding protein 2, NGFI-A-binding protein 2 |
| Target Sequences: | NM_005967 NP_005958.1 Q15742 |
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