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Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
Gene Name: | K(lysine) acetyltransferase 7 |
Synonyms: | KAT7, Histone acetyltransferase KAT7, HBO1, Lysine acetyltransferase 7, HBOA, MYST-2, MYST2, K(lysine) acetyltransferase 7, ZC2HC7 |
Target Sequences: | NM_007067 NP_008998.1 O95251 |
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