MYPT2 / PPP1R12B

protein phosphatase 1, regulatory subunit 12B

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.

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Antibodies (1)

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Primary (1)

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MYPT2 / PPP1R12B (1)

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Human (1)

Host

rabbit (1)

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IgG (1)

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polyclonal pc (1)

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Unconjugated (1)

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aa1-300 (1)

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MYPT2 / PPP1R12B Antibody (aa1-300) LS-C664326

Antibody:

MYPT2 / PPP1R12B Rabbit anti-Human Polyclonal (aa1-300) Antibody

Reactivity:

Human

Format:

Unconjugated

Price:

100 µg/$341

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