MYOC / Myocilin

myocilin, trabecular meshwork inducible glucocorticoid response

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

MYOC / Myocilin (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human MYOC / Myocilin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66343

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.8 kDa

Price:

20 µg/$1,107

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MYOC / Myocilin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123309

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.8 kDa

Price:

100 µg/$494

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Human MYOC / Myocilin Protein (Recombinant GST) (Full Length) - LS-G29426

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.18 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MYOC / Myocilin Protein (Recombinant GST, N-terminus) (aa36-135) - LS-G59332

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MYOC / Myocilin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77517

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.8 kDa

Price:

20 µg/$150

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Human MYOC / Myocilin Protein (Recombinant His) (Met1-Met504) - LS-G98625

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54.7 kDa

Price:

50 µg/$854

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Human MYOC / Myocilin Protein (Recombinant His) (aa224-471) - LS-G15906

Source:

E. coli

Tag:

His

Molecular Weight:

29.1 kDa

Price:

10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016

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