Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

MYD88

myeloid differentiation primary response 88

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Gene Name: myeloid differentiation primary response 88
Synonyms: MYD88, MYD88D
Target Sequences: NM_002468 NP_002459.2 Q99836

Publications (1)

1
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection. Tetsuya Yoshimoto, Mizuho Kittaka, Andrew Anh Phuong Doan, Rina Urata, Matthew Prideaux, Roxana E Rojas, Clifford V Harding, W Henry Boom, Lynda F Bonewald, Edward M Greenfield, Yasuyoshi Ueki. Nature communications. 2022 November;13:6648. [Full Text Article] [PubMed:36333322] [PMC:PMC9636212] Related Antibodies: LS-C357983.

☰ Filters
Products
Proteins (13)
Over-Expression Lysate (6)
Recombinant (7)
MYD88 (13)
No (13)
GST (1)
GST, N-terminus (1)
His (2)
His, N-Terminal (1)
His-GST (1)
Myc-DDK (Flag) (7)
Human (8)
Mouse (1)
Rat (1)
293T Cells (3)
E. coli (4)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (3)
MYD88 Protein
Select
E. coli
His, N-Terminal
36 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
MYD88 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
MYD88 Protein - Recombinant Myeloid Differentiation Factor 88 By SDS-PAGE
Select
E. coli
His
28.4 kDa
10 µg/$288; 50 µg/$482; 100 µg/$772; 200 µg/$965; 1 mg/$2,098; 500 µg/$1,627; 5 mg/$3,375; 2 mg/$2,288
Select
293T Cells
Myc-DDK (Flag)
33.1 kDa
20 µg/$150
MYD88 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
33.1 kDa
100 µg/$494
MYD88 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.4 kDa
100 µg/$494
MYD88 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.9 kDa
100 µg/$494
MYD88 Protein - Recombinant Myeloid Differentiation Factor 88 By SDS-PAGE
Select
E. coli
His-GST
63.9 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
MYD88 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MYD88 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.9 kDa
20 µg/$150
MYD88 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
34.4 kDa
20 µg/$150
MYD88 Protein - Purified recombinant protein MYD88 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
33.1 kDa
20 µg/$1,107
MYD88 Protein - 12.5% SDS-PAGE of human MYD88 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
58.3 kDa
2 µg/$439
Viewing 1-13 of 13 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).