MXD1 / MAD1 is a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
|Gene Name:||MAX dimerization protein 1|
|Synonyms:||MXD1, MAD1, Max dimerizer 1, Protein MAD, MAD, MAX dimerization protein 1, Max-binding protein, BHLHC58|
|Target Sequences:||NM_002357 NP_002348.1 Q05195|
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