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Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Gene Name: | biogenesis of lysosomal organelles complex-1, subunit 5, muted |
Synonyms: | BLOC1S5, DJ303A1.3, Muted homolog, Muted homolog (mouse), MU, MUTED, Protein Muted homolog |
Target Sequences: | NM_201280 NP_958437.1 Q8TDH9 |
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