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Myotubularin-related protein 3 (MTMR3), a myotubularin-related phosphatase, has been shown to contain the consensus active site of dual specificity protein phosphatases (DSPs) and to share inhibition and inactivation characteristics with other DSPs. Similar to other myotubularin-related proteins, MTMR3 has been shown to possess a SET (Suvar3-9, Enhancer of zeste, trithorax)-interacting domain (SID) which may mediate interactions with SET domains present in chromatin-organizing nuclear proteins. Additionally, MTMR3 has been shown to possess a double zinc finger (FYVE) domain at its C-terminus and to efficiently and specifically dephosphorylate phosphotidylinositol 3-phosphate (PtdIns3P) and PtdIns3,5P2 in vitro and in yeast. Thus, MTMR3 is believed to be associated with the phosphatidylinositol 3-kinase pathway, the cellular production of PtdIns5P and membrane trafficking. At least three mRNA isoforms have been hypothesized.
Gene Name: | myotubularin related protein 3 |
Family/Subfamily: | Protein Phosphatase , Myotubularin-Related |
Synonyms: | MTMR3, HMTMR3, FYVE-DSP1, Myotubularin-related protein 3, KIAA0371, ZFYVE10, Myotubularin related protein 3 |
Target Sequences: | NM_021090 NP_066576.1 Q13615 |
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