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MTHFR

methylenetetrahydrofolate reductase (NAD(P)H)

MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Gene Name: methylenetetrahydrofolate reductase (NAD(P)H)
Synonyms: MTHFR
Target Sequences: NM_005957 NP_005948.3 P42898

Publications (1)

1
Oxidative stress inhibits distant metastasis by human melanoma cells. Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Nature. 2015 527:186-91. (IHC, WB; Human) [Full Text Article] [PubMed:26466563] [PMC:PMC4644103] Related Antibodies: LS-C157974.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
MTHFR (6)
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His (2)
His-SUMO (1)
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Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Yeast (1)
MTHFR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
74.4 kDa
100 µg/$494
MTHFR Protein
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E. coli
His-SUMO
90.55 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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Yeast
His
76.6 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
MTHFR Protein - Recombinant Methylenetetrahydrofolate Reductase By SDS-PAGE
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E. coli
His
39.8 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
MTHFR Protein - Purified recombinant protein MTHFR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
74.4 kDa
20 µg/$1,107
MTHFR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
74.4 kDa
20 µg/$150
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).