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May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
Gene Name: | male-specific lethal 3 homolog (Drosophila) |
Synonyms: | MSL3, MSL3L1, MSL3-like 1, Male-specific lethal 3 homolog |
Target Sequences: | NM_006800 NP_006791.2 Q8N5Y2 |
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