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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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MSH6

mutS homolog 6

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.

Gene Name: mutS homolog 6
Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit
Target Sequences: NM_000179 NP_000170.1 P52701

☰ Filters
Products
Antibodies (62)
Primary (62)
MSH6 (62)
Human (62)
Mouse (17)
Rat (6)
Bat (1)
Dog (2)
Gibbon (3)
Guinea pig (4)
Monkey (10)
IHC (28)
IHC-Fr (2)
IHC-P (23)
WB (42)
Flo (2)
ELISA (18)
ICC (5)
IF (15)
IP (2)
Peptide-ELISA (1)
rabbit (29)
mouse (30)
goat (3)
Product Group
IHCPlus (2)
PathPlus Cancer (2)
PathPlus Cancer Pathology (2)
IgG (23)
IgG1 (16)
IgG1,k (1)
IgG2a (3)
IgG2b,k (8)
monoclonal mc (33)
polyclonal pc (29)
021 (1)
1F2 (1)
30 (2)
3A10H7 (2)
44 (3)
5B11 (2)
ABT-MSH6 (1)
G006.1 (1)
MSH6/2111 (2)
MSH6/3085 (3)
MTS6-1 (3)
OTI5D1 (2)
UMAB258 (2)
X129 (1)
Azide-free (3)
Biotin Conjugated (2)
BSA-free (3)
Carrier-free (2)
FITC Conjugated (2)
HRP Conjugated (2)
Preservative Free (2)
Ready-to-Use (3)
Unconjugated (56)
aa1-280 (4)
aa1-400 (4)
aa251-300 (4)
aa350-400 (2)
310-390 aa, Internal (1)
C-Terminus (1)
Glu371 (1)
Internal (1)
aa1300-C-term (1)
aa2-14 (1)
aa217-395 (1)
aa341-390 (1)
No (62)
MSH6 Antibody - IHC of paraffin-embedded rectum cancer tissues using MSH6 mouse monoclonal antibody with DAB staining.
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MSH6 Mouse anti-Human Monoclonal (30) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$365
MSH6 Antibody - Immunochemical staining of human MSH6 in human colon carcinoma with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
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MSH6 Rabbit anti-Human Monoclonal (Preservative Free) (021) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
50 µl/$245; 100 µl/$305
MSH6 Antibody - Anti-MSH6 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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MSH6 Mouse anti-Human Monoclonal (aa217-395) (5B11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$425
MSH6 Antibody - MSH6 Antibody in Immunohistochemistry (IHC)
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MSH6 Mouse anti-Human Monoclonal (30) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$415
MSH6 Antibody - IHC staining of FFPE human colon carcinoma with MSH6 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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MSH6 Mouse anti-Human Monoclonal (MSH6/3085) Antibody
Human
IHC-P, WB
Unconjugated
20 µg/$295; 100 µg/$465
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MSH6 Rabbit anti-Human Monoclonal (C-Terminus) Antibody
Human, Monkey
IF, WB
Unconjugated
100 µl/$575
MSH6 Antibody - IHC of MSH6 on FFPE Colon Carcinoma tissue.
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MSH6 Mouse anti-Human Monoclonal (44) Antibody
Mouse, Dog, Rat, Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$275; 0.5 ml/$435; 1 ml/$665
MSH6 Antibody - IHC of MSH6 on FFPE Colon Carcinoma tissue. This image was taken for the unmodified form of this product. Other forms have not been tested.
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MSH6 Mouse anti-Human Monoclonal (Ready-to-Use) (44) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$255; 7 ml/$325; 15 ml/$465
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MSH6 Rabbit anti-Human Monoclonal (X129) Antibody
Human
IHC
Unconjugated
40 µg/$325
MSH6 Antibody - Immunohistochemical analysis of MSH6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MSH6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$245
MSH6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
MSH6 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC-P
Unconjugated
0.1 ml/$425
Select
MSH6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$355
MSH6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
MSH6 Goat anti-Human Polyclonal (aa350-400) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$485
MSH6 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer using MSH6 antibodyat dilution of 1:100 (40x lens).
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MSH6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
IF, IHC, WB
Unconjugated
20 µl/$215; 50 µl/$235; 100 µl/$315; 200 µl/$425
MSH6 Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using MSH6 antibody.
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MSH6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$215; 50 µl/$235; 100 µl/$315; 200 µl/$425
MSH6 Antibody - Western blot of GTBP antibody
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MSH6 Rabbit anti-Human Polyclonal (310-390 aa, Internal) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µl/$235; 100 µl/$265; 200 µl/$335
MSH6 Antibody - IHC of GTBP (E371) pAb in paraffin-embedded human brain tissue.
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MSH6 Rabbit anti-Human Polyclonal (Glu371) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$345
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MSH6 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$375
MSH6 Antibody - Anti-MSH6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MSH6 Goat anti-Human Polyclonal (aa2-14) Antibody
Mouse, Rat, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
MSH6 Antibody - Immunofluorescence of monoclonal antibody to MSH6 on HeLa cell . [antibody concentration 10 ug/ml]
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MSH6 Mouse anti-Human Monoclonal (1F2) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$365
MSH6 Antibody - Immunohistochemistry of paraffin-embedded human testis using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MSH6 Rabbit anti-Human Polyclonal (aa1-400) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$285; 100 µg/$385
MSH6 Antibody - Colon Carcinoma 1
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MSH6 Mouse anti-Human Monoclonal (ABT-MSH6) Antibody
Human
IHC, WB
Unconjugated
50 µl/$265; 100 µl/$325
MSH6 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MSH6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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MSH6 Mouse anti-Human Monoclonal (aa1-280) (OTI5D1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$345
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MSH6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
IF, IHC, WB
Unconjugated
60 µl/$235; 120 µl/$295; 200 µl/$395
Select
MSH6 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
50 µl/$235; 100 µl/$275; 200 µl/$305
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).