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MSH4
mutS homolog 4
MSH4 is a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
| Gene Name: | mutS homolog 4 |
| Synonyms: | MSH4, MutS (E. coli) homolog 4, HMSH4, MutS homolog 4 (E. coli), MutS protein homolog 4 |
| Target Sequences: | NM_002440 NP_002431.2 O15457 |
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