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Lynnwood, WA 98036
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MS4A2 / FCERI
membrane-spanning 4-domains, subfamily A, member 2
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
| Gene Name: | membrane-spanning 4-domains, subfamily A, member 2 |
| Synonyms: | MS4A2, ATOPY, FcERI, FCER1B, IGER, IgE Fc receptor subunit beta, IGHER, IGEL, APY, IgE responsiveness (atopic) |
| Target Sequences: | NM_000139 NP_000130.1 Q01362 |
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