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MPO / Myeloperoxidase

myeloperoxidase

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. The gene for MPO is translocated in patients with acute promyelocytic leukemia and is mutated in hereditary MPO deficiency.

Gene Name: myeloperoxidase
Synonyms: MPO, Myeloperoxidase precursor, Myeloperoxidase
Target Sequences: NM_000250 NP_000241.1 P05164

Publications (7)

1
The glycosylation of myeloperoxidase. Ravnsborg T, Houen G, Hjrup P. Biochimica et biophysica acta. 2010 1804:2046-53. (ELISA; Human) [PubMed:20621206]
2
Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Sun Q, Zhong W, Zhang W, Zhou Z. American journal of physiology. Gastrointestinal and liver physiology. 2016 310:G205-14. (IHC; Human) [Full Text Article] [PubMed:26585415] [PMC:PMC4971814]
3
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Liver international : official journal of the International Association for the Study of the Liver. 2017 July;37:968-973. [Full Text Article] [PubMed:28345165] [PMC:PMC5479767]
4
Adenovirus 14p1 Immunopathogenesis during Lung Infection in the Syrian Hamster. Jay R Radke, Hunter J Covert, Fredrick Bauer, Vijayalakshmi Ananthanarayanan, James L Cook. Viruses. 2020 May;12: [Full Text Article] [PubMed:32486177] [PMC:PMC7354616] Related Antibodies: LS-C388920.
5
Decreased neutrophil levels in mice with traumatic brain injury after cape administration. Rizha Anshori Nasution, Andi Asadul Islam, Mochammad Hatta, Prihantono. Annals of medicine and surgery (2012). 2020 May;54:89-92. [Full Text Article] [PubMed:32419943] [PMC:PMC7217774]
6
Essential Role of IFN-? in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice. Ruichao Yue, Xiaoyuan Wei, Jiangchao Zhao, Zhanxiang Zhou , Wei Zhong. Frontiers in physiology. 2021 Jan;11:629141. [Full Text Article] [PubMed:33536944] [PMC:PMC7848155]
7
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
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MPO / Myeloperoxidase Antibody - Anti-MPO / Myeloperoxidase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer Pathology
Cancer
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (3E11) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MPO / Myeloperoxidase Antibody - Anti-MPO / Myeloperoxidase antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Cancer Pathology
Cancer
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (9B12G7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MPO / Myeloperoxidase Antibody - Anti-MPO / Myeloperoxidase antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$775
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MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (FITC) (8F4) Antibody
Mouse
Flo, IHC, IHC-Fr
FITC Conjugated
100 µg/$807
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MPO / Myeloperoxidase Human anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
2 ml/$467
MPO / Myeloperoxidase Antibody - Western blot of recombinant MPO / Myeloperoxidase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal (aa253-718) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
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MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (FITC) (2D4) Antibody
Mouse, Rat
Flo
FITC Conjugated
100 µg/$863
MPO / Myeloperoxidase Antibody
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MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal (aa139-252) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
MPO / Myeloperoxidase Antibody - IHC-P: Myeloperoxidase antibody testing of human liver cancer tissue
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MPO / Myeloperoxidase Rabbit anti-Human Polyclonal (aa714-728) Antibody
Hamster, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
MPO / Myeloperoxidase Antibody - Anti-MPO / Myeloperoxidase antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$460
MPO / Myeloperoxidase Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$460
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MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
1 ml/$505
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
250 - 16000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$590
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Horse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$795
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
MPO / Myeloperoxidase ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
MPO / Myeloperoxidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$600
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MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (8F4) Antibody
Mouse, Rat
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$723
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MPO / Myeloperoxidase Mouse anti-Human Monoclonal (4A4) Antibody
Human
ELISA
Unconjugated
1 mg/$973
MPO / Myeloperoxidase ELISA Kit
Select
Sandwich
96-Well Microplate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Saliva, Serum, Urine
1 Plate/$559
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MPO / Myeloperoxidase Mouse anti-Human Monoclonal (Concentrated) (HRP) (2C7) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
HRP Conjugated, Concentrated
0.2 mg/$735
MPO / Myeloperoxidase Antibody - Rabbit antibody to MPO. IHC-P on paraffin sections of human small intestine. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through a 0.2 micron filter. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions, using DAB chromogen. Primary antibody: dilution 1:1000, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin. Primary antibody: dilution 1:1000, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.
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MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
100 µl/$393
MPO / Myeloperoxidase Antibody - Intracellular staining of human peripheral blood with anti-myeloperoxidase (MPO421-8B2) FITC.
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MPO / Myeloperoxidase Mouse anti-Human Monoclonal (FITC) (MPO421-8B2) Antibody
Human
ELISA, Flo
FITC Conjugated
100 Tests/$337
MPO / Myeloperoxidase Antibody - MPO antibody (0.3 ug/ml) staining of Human Peripheral Blood Lymphocyte lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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MPO / Myeloperoxidase Goat anti-Human Polyclonal (aa74-86) Antibody
Rabbit, Hamster, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Viewing 1-25 of 230 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).