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Mouse IgG3

The fragment antigen-binding (Fab fragment) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. These domains shape the paratope — the antigen-binding site — at the amino terminal end of the monomer. The two variable domains bind the epitope on their specific antigens. In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')2 fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')2 fragment can be split into two Fab' fragments by mild reduction.

Mouse IgG3 Target Details

Target Name: Mouse IgG3

Publications (2)

1
Tolerogenic properties of liver macrophages in non-alcoholic steatohepatitis. Lorenzo A Orci, Mario Kreutzfeldt, Nicolas Goossens, Laura Rubbia-Brandt, Florence Slits, Karim Hammad, Vaihere Delaune, Graziano Oldani, Francesco Negro, Sophie Clément, Carmen Gonelle-Gispert, Léo H Buhler, Christian Toso, Stéphanie Lacotte. Liver international : official journal of the International Association for the Study of the Liver. 2020 March;40:609-621. [Full Text Article] [PubMed:31872499] Related Antibodies: LS-C209483.
2
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping. Giovanni Di Liberto, Stanislav Pantelyushin, Mario Kreutzfeldt, Nicolas Page, Stefano Musardo, Roland Coras, Karin Steinbach, Ilena Vincenti, Bogna Klimek, Thomas Lingner, Gabriela Salinas, Nathalie Lin-Marq, Ori Staszewski, Marta Joana Costa Jordão, Ingrid Wagner, Kristof Egervari, Matthias Mack, Camilla Bellone, Ingmar Blümcke, Marco Prinz, Daniel D Pinschewer, Doron Merkler. Cell. 2018 October;175:458-471.e19. [Full Text Article] [PubMed:30173917] Related Antibodies: LS-C209483.

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ELISA Kits (3)
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Mouse IgG3 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Mouse IgG3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Mouse IgG3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).