Mouse IgG2a

The fragment antigen-binding (Fab fragment) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. These domains shape the paratope — the antigen-binding site — at the amino terminal end of the monomer. The two variable domains bind the epitope on their specific antigens. In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')2 fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')2 fragment can be split into two Fab' fragments by mild reduction.

Mouse IgG2a Target Details

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Products

ELISA Kits (2)

Type

Sandwich (1)

Sandwich CLIA (1)

Target

Mouse IgG2a (2)

Reactivity

Mouse (2)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

Publications

No (2)

Sample Type

Plasma (2)

Serum (2)

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Mouse IgG2a (Sandwich ELISA) ELISA Kit - LS-F22693

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

7.81 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

Select

Mouse IgG2a (CLIA) ELISA Kit - LS-F30797

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

1.563 - 100 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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