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MORF / MYST4

K(lysine) acetyltransferase 6B

MORF / MYST4 is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene.

Gene Name: K(lysine) acetyltransferase 6B
Synonyms: KAT6B, Histone acetyltransferase MOZ2, Histone acetyltransferase MORF, KIAA0383, MOZ2, MYST-4, K(lysine) acetyltransferase 6B, Querkopf, MORF, MOZ-related factor, ZC2HC6B, GTPTS, MYST4, Qkf
Target Sequences: NM_012330 NP_036462.2 Q8WYB5

Publications (1)

1
Phospho-?Np63a/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Ratovitski EA. Cell cycle (Georgetown, Tex.). 2014 13:749-61. (WB; Human) [Full Text Article] [PubMed:24394434] [PMC:PMC3979911]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).