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MMS21 / NSMCE2

non-SMC element 2, MMS21 homolog (S. cerevisiae)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

Gene Name: non-SMC element 2, MMS21 homolog (S. cerevisiae)
Synonyms: NSMCE2, C8orf36, E3 SUMO-protein ligase NSE2, MMS21, HMMS21, Non-SMC element 2 homolog, NSE2, MMS21 homolog
Target Sequences: AF147336 Q96MF7 Q96MF7

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
MMS21 / NSMCE2 (4)
No (4)
GST (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
MMS21 / NSMCE2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
27.8 kDa
100 µg/$494
MMS21 / NSMCE2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.8 kDa
20 µg/$150
MMS21 / NSMCE2 Protein
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E. coli
His, N-Terminal
27.8 kDa
50 µg/$419
MMS21 / NSMCE2 Protein - 12.5% SDS-PAGE of human NSMCE2 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.3 kDa
10 µg/$479; 25 µg/$670
Viewing 1-4 of 4 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).