MMS21 / NSMCE2

non-SMC element 2, MMS21 homolog (S. cerevisiae)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

MMS21 / NSMCE2 (4)

Publications

No (4)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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MMS21 / NSMCE2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105290

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

100 µg/$494

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Human MMS21 / NSMCE2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83735

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

20 µg/$150

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Human MMS21 / NSMCE2 Protein (Recombinant His, N-Terminal) - LS-G144469

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

27.8 kDa

Price:

50 µg/$419

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Human MMS21 / NSMCE2 Protein (Recombinant GST) (Full Length) - LS-G37252

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.3 kDa

Price:

10 µg/$479; 25 µg/$670

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