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MMS19
MMS19 nucleotide excision repair homolog (S. cerevisiae)
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
| Gene Name: | MMS19 nucleotide excision repair homolog (S. cerevisiae) |
| Synonyms: | MMS19, MET18, MMS19-like protein, MET18 homolog, MMS19L, HMMS19, Homolog of yeast MMS19 |
| Target Sequences: | NM_022362 NP_071757.4 Q96T76 |
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