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Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
Gene Name: | matrix metallopeptidase 24 (membrane-inserted) |
Family/Subfamily: | Protease , Metallopeptidase M10A |
Synonyms: | MMP24, Matrix metalloproteinase-24, MMP-24, MT-MMP 5, MT-MMP5, MT5-MMP, MTMMP5, MT5MMP |
Target Sequences: | NM_006690 NP_006681.1 Q9Y5R2 |
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