Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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GPR38, also called Motilin Receptor, mediates smooth muscle contraction and controls gastrointestinal motility by binding motilin. The antibiotic erythromycin-A also induces smooth muscle contraction when binding to the motilin receptor. Two variants are produced by alternative splicing. Associations exist between the motilin peptide and several gastrointestinal diseases (such as Crohn's disease, inflammatory bowel disease, and ulcerative colitis), suggesting that the motilin receptor may also be implicated in these diseases.