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MKRN1

makorin ring finger protein 1

MKRN1 is a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: makorin ring finger protein 1
Synonyms: MKRN1, Makorin ring finger protein 1, RNF61, RING finger protein 61
Target Sequences: NM_013446 NP_038474.2 Q9UHC7

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
MKRN1 (7)
No (7)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
MKRN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
MKRN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
MKRN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.2 kDa
20 µg/$150
MKRN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.2 kDa
100 µg/$494
MKRN1 Protein - 12.5% SDS-PAGE of human MKRN1 stained with Coomassie Blue
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Wheat Germ Extract
GST
79.8 kDa
2 µg/$439
MKRN1 Protein - Purified recombinant protein MKRN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.2 kDa
20 µg/$1,107
MKRN1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Viewing 1-7 of 7 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).