MKNK2 / MNK2

MAP kinase interacting serine/threonine kinase 2

MKNK2 / MNK2 is a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

MKNK2 / MNK2 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MKNK2 / MNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87381

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$150

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Human MKNK2 / MNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87382

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$215

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MKNK2 / MNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112385

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

100 µg/$494

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Human MKNK2 / MNK2 Protein (Recombinant His, N-Terminal) - LS-G144077

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

46.5 kDa

Price:

50 µg/$419

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Human MKNK2 / MNK2 Protein (Recombinant GST) (Full Length) - LS-G28705

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.12 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MKNK2 / MNK2 Protein (Recombinant GST, N-terminus) (aa41-158) - LS-G58738

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MKNK2 / MNK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70543

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$1,107

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MKNK2 / MNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103495

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

100 µg/$710

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