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Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca2+, avoiding energy dissipation and cell-death triggering.
Gene Name: | mitochondrial calcium uptake 2 |
Synonyms: | MICU2, EF hand domain family A1, EFHA1, Smhs2 homolog |
Target Sequences: | Q8IYU8 Q8IYU8 |
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