MICU1 / CBARA1

mitochondrial calcium uptake 1

Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca2+ concentration, allowing a rapid response of mitochondria to Ca2+ signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.

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Proteins (4)

Type

Recombinant (4)

Target

MICU1 / CBARA1 (4)

Publications

No (4)

Tag

GST (2)

His, N-Terminal (1)

Myc-DDK (Flag) (1)

Species

Human (4)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MICU1 / CBARA1 Protein (Recombinant GST) - LS-G132139

Tag:

GST

Molecular Weight:

36.63kDa

Price:

10 µg/$479; 25 µg/$670

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Human MICU1 / CBARA1 Protein (Recombinant His, N-Terminal) - LS-G144535

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

54.4 kDa

Price:

50 µg/$419

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Human MICU1 / CBARA1 Protein (Recombinant GST) (Full Length) - LS-G32106

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.8 kDa

Price:

2 µg/$439

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Human MICU1 / CBARA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69840

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.4 kDa

Price:

20 µg/$1,107

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