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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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MICB
MHC class I polypeptide-related sequence B
MICB is a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
| Gene Name: | MHC class I polypeptide-related sequence B |
| Synonyms: | MICB, MHC class I mic-B antigen, MIC-B, PERB11.2 |
| Target Sequences: | NM_005931 NP_005922.2 Q29980 |
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