MICAL2

microtubule associated monooxygenase, calponin and LIM domain containing 2

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MICAL2 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

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MICAL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113817

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

100 µg/$494

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Human MICAL2 Protein (Recombinant) - LS-G143843

Source:

E. coli

Tag:

None

Molecular Weight:

74.7 kDa

Price:

50 µg/$419

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Human MICAL2 Protein (Recombinant His) (aa1-495) - LS-G23024

Source:

Yeast

Tag:

His

Molecular Weight:

58.48 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human MICAL2 Protein (Recombinant GST, N-terminus) (aa1021-1123) - LS-G61210

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MICAL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82149

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

20 µg/$150

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