MIB1

mindbomb E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

MIB1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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MIB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111013

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110 kDa

Price:

100 µg/$710

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Human MIB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86955

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110 kDa

Price:

20 µg/$215

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Human MIB1 Protein (Recombinant His) (aa5-332) - LS-G22596

Source:

E. coli

Tag:

His

Molecular Weight:

40.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MIB1 Protein (Recombinant GST, N-terminus) (aa909-1006) - LS-G62968

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MIB1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70388

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110 kDa

Price:

20 µg/$1,107

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Human MIB1 Protein (Recombinant His-T7) (aa769-1000) - LS-G16159

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.4 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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