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MFNG / Manic Fringe

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

MFNG / Manic Fringe is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.

Gene Name:	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms:	MFNG, Manic fringe
Target Sequences:	NM_002405 NP_002396.2 O00587

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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